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Petr Vladimirovich Lebedev-Stepanov, Dr.
Marina Eduardovna Buzoverya, Dr.
Irina Shishpor
Konstantin Olegovich Vlasov
Yulia Pavlovna Potekhina, Prof.


Motivation: It is important to develop the high-precision computerized methods for medical rapid diagnostic which is generalizing the unique clinical experience obtained in the past decade as specialized solutions for diagnostic problems of control of specific diseases and, potentially, for a wide health monitoring of virtually healthy population, identify the reserves of human health and take the actions to prevent of these reserves depletion. In this work we present one of the new directions in bioinformatics, i.e. medical diagnostics by automated expert system on basis of morphology analysis of digital image of biological liquid dried pattern.

Results: Proposed method is combination of bioinformatics and biochemistry approaches for obtaining diagnostic information from a morphological analysis of standardized dried patterns of biological liquid sessile drop. We have carried out own research in collaboration with medical diagnostic centers and formed the electronic database for recognition the following types of diseases: candidiasis; neoplasms; diabetes mellitus; diseases of the circulatory system; cerebrovascular disease; diseases of the digestive system; diseases of the genitourinary system; infectious diseases; factors relevant to the work; factors associated with environmental pollution; factors related to lifestyle. The laboratory setup for diagnostics of the human body in pathology states is developed. The diagnostic results are considered.

Availability: Access to testing the software can be obtained on request to the contact email below.

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How to Cite
LEBEDEV-STEPANOV, Petr Vladimirovich et al. MEDICAL DIAGNOSTICS BY MICROSTRUCTURAL ANALYSIS OF BIOLOGICAL LIQUID DRIED PATTERNS AS A PROBLEM OF BIOINFORMATICS. Journal of Bioinformatics and Genomics, [S.l.], n. 1 (6), feb. 2018. ISSN 2530-1381. Available at: <>. Date accessed: 11 aug. 2020. doi:
Bioimage informatics
Brutin D. (2015) Droplet Wetting and Evaporation. From Pure to Complex Fluids. Academic Press. 464 P.
Buzoverya M.E., Shishpor I.V., Potekhina Yu.P., Shcher-bak Yu.P. (2012) The bio-liquids’ microstructural analysis. Technical Physics. 2012; 82;87; 123-128. doi: 10.1134/S1063784212070079.
Buzoverya M.E., Shishpor I.V., Sadovoy S.A. (2013) Quantitative microscopy of images of dendrite structure ob-jects. Certification on official registration of computer program No2013610336 (RU).
Lebedev-Stepanov P.V., Vlasov K.O. (2013) Simulation of self-assembly in an evaporating droplet of colloidal solution by dissipative particle dynamics. Colloids and Surfaces A: Physicochem. Eng. Aspects. 432; 132– 138. doi: 10.1016/j.colsurfa.2013.05.012.
Li W., Lee M.S. (2014) Dried Blood Spots: Applications and Techniques. John Wiley & Sons. 364 P.
Shabalin V.N., Shatokhina S.N. (2001) Morfologiya biolo-gicheskikh zhidkostey cheloveka. [Morphology of the biological liquids of the human]. Мoscow: Khrizostom.
Topol E. (2012) How the Digital Revolution Will Create Better Health Care, Basic Books, 303 P.