NUCLEOLIN AND NUCLEOPHOSMIN AS EXPECTED TARGETS FOR CATIONIC PEPTIDES, INDUCING TUMOR CELL APOPTOSIS

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Anna Alexandrovna Lushnikova
Daria Andreevna Ponkratova
Alexandr Vladislavovich Kostarev
Anna Andreevna Rudakova
Sergej Mikhailovich Andreev
Maria Anatol'evna Baryshnikova

Abstract

Three original cell lines mel IS, mel H and mel Ki obtained from the lymph nodes of the patients with metastatic cutaneous melanoma were used as a models for study  selective cytotoxicity of  7 cationic peptides. Nucleolin (NCL, C23) and nucleophosmin (NPM, B23) are the most abundant nucleolar  chaperone proteins over-expressed in tumor cells. They are considered now as the cell proliferation markers and potential targets for cancer treatment. Simulation for peptides and NCL/NPM interactions by molecular docking   allows to characterize tested  cationic peptides  as a ligands for these proteins. Binding between the  peptides and  cell surface nucleolin might  trigger  subsequent tumor cell  apoptosis. The data obtained create the base for use the peptides as potent  antitumor agents with high selective activity and  low toxicity. 

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How to Cite
LUSHNIKOVA, Anna Alexandrovna et al. NUCLEOLIN AND NUCLEOPHOSMIN AS EXPECTED TARGETS FOR CATIONIC PEPTIDES, INDUCING TUMOR CELL APOPTOSIS. Journal of Bioinformatics and Genomics, [S.l.], n. 3 (8), aug. 2018. ISSN 2530-1381. Available at: <http://journal-biogen.org/article/view/94>. Date accessed: 24 sep. 2018. doi: http://dx.doi.org/10.18454/jbg.2018.3.8.1.
Section
Research in Biology using computation
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