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Three original cell lines mel IS, mel H and mel Ki obtained from the lymph nodes of the patients with metastatic cutaneous melanoma were used as a models for study selective cytotoxicity of 7 cationic peptides. Nucleolin (NCL, C23) and nucleophosmin (NPM, B23) are the most abundant nucleolar chaperone proteins over-expressed in tumor cells. They are considered now as the cell proliferation markers and potential targets for cancer treatment. Simulation for peptides and NCL/NPM interactions by molecular docking allows to characterize tested cationic peptides as a ligands for these proteins. Binding between the peptides and cell surface nucleolin might trigger subsequent tumor cell apoptosis. The data obtained create the base for use the peptides as potent antitumor agents with high selective activity and low toxicity.
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