CYTPOWER: IMPLEMENTATION OF CYTOTOXIC POWER CONCEPT IN PYTHON

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Maxim Terpilowski
Nikolay Goncharov

Abstract

Currently existing methods and parameters are inadequate for representative and quanititative assessment of cytotoxic activity of chemical compounds. Recently, we have introduced a concept of cytotoxic power which provides an effective way to a reasonable estimation and comparative analysis of cytotoxic activity of chemical agents. The basis of this concept is an integrative parameter that relies on important toxicological principles: dose of compound related to a cell number and exposure-time-response relationship of its activity.


Herein, we propose an implementation of our concept of cytotoxic power as a package developed in Python programming language. The package is free and available on GitHub repository.

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How to Cite
Terpilowski, M., & Goncharov, N. (2018). CYTPOWER: IMPLEMENTATION OF CYTOTOXIC POWER CONCEPT IN PYTHON. JOURNAL OF BIOINFORMATICS AND GENOMICS, (4 (9). https://doi.org/10.18454/jbg.2018.4.9.1
Section
Novel computational tools and databases

References

Saeed W.K., Jun D.W. Necroptosis: An emerging type of cell death in liver diseases // World J Gastroenterol. — 2014. — Т. 20. — №. 35. — С. 12526-12532

Smetanin I.A., Novikov M.S., Agafonova A.V., Rostovskii N.V., Khlebnikov A.F., Kudryavtsev I.V., Terpilowski M.A., Serebriakova M.K., Trulioff A.S., Goncharov N.V. A novel strategy for the synthesis of thermally stable and apoptosis-inducing 2,3-dihydroazetes // Org. Biomol. Chem. – 2016. – Т. 14. – №. 19. – С. 4479-4487.

Galenko E.E., Galenko A.V., Novikov M.S., Khlebnikov A.F., Kudryavtsev I.V., Terpilowski M.A., Serebriakova M.K., Trulioff A.S., Goncharov N.V. 4-Diazo and 4-(triaz-1-en-1-yl)-1H-pyrrole-2-carboxylates as agents inducing apoptosis. Chemistry Select. — 2017. – Т. 2. – №. 25. – С. 7508-7513.

Thompson C. B. Apoptosis in the pathogenesis and treatment of disease //Science. – 1995. – Т. 267. – №. 5203. – С. 1456-1462.

Potten C. S. What is an apoptotic index measuring? A commentary //British journal of cancer. – 1996. – Т. 74. – №. 11. – С. 1743.

Henery S., George T., Hall B., Basiji D., Ortyn W., Morrissey P. Quantitative image based apoptotic index measurement using multispectral imaging flow cytometry: a comparison with standard photometric methods //Apoptosis. – 2008. – Т. 13. – №. 8. – С. 1054.

Mooney E. E., Peris J. R., O'Neill A., Sweeney E. C. Apoptotic and mitotic indices in malignant melanoma and basal cell carcinoma //Journal of clinical pathology. – 1995. – Т. 48. – №. 3. – С. 242-244.

Goncharov N. V., Terpilowski M. A., Nadeev A. D., Kudryavtsev I. V., Serebriakova M. K., Zinchenko V. P., Avdonin P. V. Cytotoxic Power of Hydrogen Peroxide Effect on Endothelial Cells in vitro //Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology. – 2018. – Т. 12. – №. 2. – С. 180-188.