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Increased Expression of AKR1C2 and AKR1B1 Genes is Associated with the Development of Resistance to Docetaxel in Prostate Cancer

Table 1 - Summary results of AkRs genes differential expression across different experimental cell groups

​Gene

Log2FC1

FDR1

Log2FC2

FDR2

Log2FC3

FDR3

AKR7A3

​0,84

1,0E+00

​0,57

1,0E+00

​0,81

1,0E+00

AKR1A1

​0,05

1,0E+00

​0,18

8,0E-01

​0,35

4,7E-02

AKR7A2

​0,28

8,2E-01

​0,51

3,2E-02

​0,85

3,0E-05

AKR1B1

​1,09

7,5E-02

​2,26

7,0E-05

​1,67

1,7E-03

AKR1B10

​1,13

3,3E-02

​3,41

2,1E-08

​1,66

6,5E-04

AKR1C3

​0,3

1,0E+00

​2,2

7,9E-06

​0,9

8,5E-02

AKR1E2

​0,66

1,0E+00

​1,09

7,7E-01

​0,7

1,0E+00

AKR1C2

​1,67

3,1E-02

​7,61

1,5E-07

​3,34

5,4E-05

AKR1C1

​1,03

5,2E-02

​2,51

1,5E-06

​1,07

3,0E-02

Log2FC – fold change in expression, binary logarithm; FDR - false discovery rate; 1- Control vs. DoX 10nM, 2 - 4nM vs. DoX 10nM, 3-8nM vs. DoX 10nM