THE ROLE OF MITOCHONDRIA IN THE FORMATION OF THE BIOPHYSICAL POTENTIAL OF THE BODY AND THE MANIFESTATION OF HETEROSIS
Main Article Content
Abstract
A retrospective analysis of the theoretical developments of the causes of the phenomenon of heterosis has been carried out. In connection with new scientific achievements of the fundamental sciences, various hypotheses of heterosis have been revised. A new hypothesis has been proposed, according to which heterosis is explained by the relationship between genetic heterozygosity and the high initial potential of free energy of germ cells, caused by increased work and reproduction of mitochondria. This work of mitochondria is regulated by the hypothalamus in response to signaling by free radicals and humanin of the conditions of interaction between the nuclear and mitochondrial DNA of parental individuals of different breeds (cultivars) caused by environmental factors, for example, stress, a certain force within the limits of the species reaction. As a result of incomplete interaction between nDNA and mtDNA of different breeds, a sharp increase in the work of mitochondria occurs, enriching the hybrid with energy, which is accepted as hybrid strength or heterosis. Various ways of improving the work of mitochondria are considered, which can enhance heterosis and, at the same time, increase the productivity of animals and plants.
Downloads
Metrics
Article Details
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
References
Bekenev V.A. Technology of breeding and keeping pigs : Textbook / V.A. Bekenev. — St. Petersburg: Publishing house "Lan". — 2012. — P. 184-205
Bekenev V.A. Genetic information and energy potential are the basis of heterosis and inbred depression / V.A. Bekenev // Bulletin of RASKHN, 2008. — 3. — P. 80-81.
Kushner H.F. The genetic nature of heterosis / H.F. Kushner // Problems of zootechnical genetics. — M. : Nauka, 1969. — P. 39-62.
Mather K. The genetical basis of geterosis / K. Mather // Proc.Royal Soc. — 1955. — P. 144.
Lerner J.M. Genetic gomeostasis / J.M. Lerner // Edinburgh. — 1954. — 134 p.
Kirрichnikov V.S. Genetic mechanisms and evolution of heterosis / V.S. Kirрichnikov // Rus. J. Genetics. — 1974. — Vol. 10. — № 4. — P. 165-179.
Strunnikov V.A. A new hypothesis of heterosis, its scientific and practical significance / V.A. Strunnikov // Bulletin of Agricultural Sciences. — 1983. — No. 1. —P. 34-40.
Shakhbazov V.G. Connection of the duration of ontogenesis with the effect of heterosis and some mechanisms of this connection / V.G. Shakhbazov // Leading factors of ontogenesis. — Kiev: Naukova dumka, 1972. — P. 266-281.
Leslie J.F. Genetic bases of breeding of farm animals / J.F. Leslie. — Moscow : Kolos, 1982. — P. 222-262.
Shull G.H. Beginnings of the geterosis concept / G.H. Shull // Heterosis N.Y.: Jowa State Coll. 1952. — P. 14.
Bauer E.S. Theoretical biology / E.S. Bauer. — M.-L., 1935. — 205 p.
Prigozhin I. Introduction to the thermodynamics of irreversible processes / I. Prigozhin. — M.: Publishing House of inostr. lit., 1960. — 127 p.
Voeykov V.A. Bio-physico-chemical aspects of aging and longevity / V.A. Voeykov // Successes of Gerontology, 2002, . — P. 261
Bekenev V.A. Heterosis and inbreeding in animals in the light of the principle of E.S. Bauer / V.A. Bekenev // Ways to improve the efficiency of agricultural production: Collection of articles by young scientists of Siberia and the Far East. — Novosibirsk, 1974. — Part 1. — P. 57-59.
Bekenеv V.A. The problem of animal reproduction from the positions of some theoretical biology areas / V.A. Bekenеv, A.A. Muratov // Life Science Journal, 2014. — 11(9):151-155
Bekenev V.A. Genetic information and energy potential — the basis of heterosis and inbred depression / V.A. Bekenev. // Bulletin of RASKHN, 2008, No. 3. — P. 80-81.
Marks H.L. Performance of crosses of Quail selected under Different Environments / H.L. Marks // J. of Heredity, 1973. — Vol. 64, №2. — P. 73.
Rich S.S. Genotipe- environment interaction effect in long-term selected populations of Tribolium / Rich S.S., Bell A.E. // The Journal of Heredity, 1980. — Vol. 71. — № 5. — P. 319-322.
Clarke J.M. The genetics and cytology of Drosofila subobscura . X1 Hibrid vigour and longevity / J.M. Clarke, J. Maynard Smith // Genetic. — 1955. — № 53. — P. 172.
Prudov A.I. Related breeding and duration of economic use of cows / A.I. Prudov // Scientific tr. Krasnoyarsk Agricultural Institute. — Krasnoyarsk, 1957. — Vol. I. — P. 12-16. — No. 5. — P. 275-286.
Belenkov E.P. Comparative study of various forms of crossing in pig breeding / E.P. Belenkov // Methods of pig breeding. — M.: Kolos, 1965. — P. 65-69.
Dogadaev A.M. The influence of inbreeding on morphological and biochemical parameters of eggs and productivity of Russian white chickens: abstract of the dis... of PhD in Biological Sciences / A.M. Dogadaev. — M., 1969. — 18 p.
Moiseeva I.G. Influence of inbreeding on the quality of chicken eggs / I.G. Moiseeva // Genetics. — 1970. — Vol. 6. — No. 6. — P. 99-107.
Kryshchiunas R-P.M. The influence of related mating on the growth, development and reproductive ability of bulls of the red Lithuanian breed: abstract of the dis. of PhD in Agricultural Sciences / Kryshchiunas R-P.M. — Dubrovitsy, 1978. — P. 17.
Stolbov V.M. The influence of the origin of bulls on the quality and fertilizing ability of their sperm: collection of the Scientific works / V.M. Stolbov, L.N. Bakhmut, L.D. Rimareva. — VNIIRGZH. — L., 1979. — No. 27. — P. 5-12.
Mitteldorf J. Mitochondria in Aging / J. Mitteldorf // I, II: Remedies. — URL: https://joshmitteldorf.scienceblog.com/2017/07/14/mitochondria-in-aging-i-mechanisms-and-background (accessed: 10.03.2023)
Richard H. Haas. Mitochondrial Dysfunction in Aging and Diseases of Aging / Richard H. Haas // Biology (Basel). 2019 Jun 17; 8(2). 48. — DOI: 10.3390/biology8020048
Lane Nick. Energy, sex, suicide. Mitochondria and the meaning of life / Nick Lane. — 2016. — 251 p.
Bekenev V.A. Productive longevity of animals, methods of its prediction and prolongation (review) / V.A. Bekenev // Agricultural Biology, 2019. —Volume 54, 4. — P. 655-666. — DOI: 10.15389/agrobiology.2019.4.655rus
Kalyuzhnov V.T. A new approach to solving the problem of heterosis / V.T. Kalyuzhnov, V.A. Bekenev, K.Ya. Motovilov // Genetics, 1982. — Vol. 18. — No. 1. —P. 145-153.
Mitochondrial Booster for Longer Healthspans and Longer Life // A Special Report by the Transformational Technology AlertTeam. Mauldin economics. BULL or BUST. Navigating the High-Speed Train Wreck. — 2016.
Barzilai N. Unique Lipoprotein Phenotype and Genotype Associated With Exceptional Longevity / N. Barzilai. — JAMA 290, 2030 (2003).
Kim S.J. The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus / S.J. Kim, N. Guerrero, G. Wassef [et al.]. — Oncotarget, 2016, 26, 7(30): 46899-46912. — DOI: 10.18632/oncotarget.10380.
Stephen S. Hall. Feature: The man who wants to beat back aging / Stephen S. Hall. — Sep. 16, 2015. — URL: www.sciencemag.org «news»2015/09 (accessed: 10.03.2023).
Yen K. The emerging role of the mitochondrial-derived peptide humanin in stress resistance / K. Yen, C. Lee, H. Mehta [et al.]. — J Mol Endocrinol. 2013 Jan 11; 50(1): R11-9. — DOI: 10.1530/JME-12-0203.
Walter G Bottje. Board invited review: Oxidative stress and efficiency: the tightrope act of mitochondria in health and disease / Walter G Bottje. — J Anim Sci., 2019, 97, 8: 3169-3179. — DOI: 10.1093/jas/skz219.