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Интеграция генетических факторов риска и лекарственно-ассоциированных генов при терапии биполярного расстройства: биоинформатический и системно-фармакологический анализ сигнальных путей
Pathway enrichment across BD mapping and drug-evidence layers
cell values are g:SCS-adjusted p-values; grey cells did not meet p < 0.05, and white cells indicate that the term was not returned; the strict BD set had no significant corrected term; high voltage-gated calcium channel activity was significant only in the functionally expanded BD set; tier 1 calcium signaling was driven by receptor genes; tier 3 PK and the one-gene PGx layer are shown separately; source values and term-level intersections are provided in Supplementary Table S24